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They arise during development from oligodendrocyte precursor cells (opcs), which can be identified by their expression of a number of antigens, including the ganglioside gd3, the ng2 chondroitin sulfate proteoglycan, and the platelet-derived growth factor-alpha receptor subunit(pdgf-alphar). Mature oligodendrocytes are broadly classified into either myelinating or non-myelinating satellite oligodendrocytes. Mature oligodendrocytes express integral membrane proteins including myelin basic protein (mbp), myelin-associated glycoprotein (mag), myelin oligodendrocyte glycoprotein, and proteolipid protein (plp). 137 myelin plp (30 kda) is the most abundant protein in cns myelin, and its spliced variant is dm-20 (26 kda). In contrast, differentiated mature oligodendrocytes (ol) were found to be significantly affected by cuprizone treatment. This was accompanied by a reduced mitochondrial potential in cuprizone-treated ol. These results demonstrate that the main toxic target for cuprizone is mature ol, whilst other glial cells including opc are not or only. Progenitor, postmitotic and mature oligodendrocytes in embryonic , postnatal and adult brain. Im studying oligodendrocyte differentiation and galc is one of the antibodies i use to detect mature oligodendrocytes (together with mbp). Division following experimental demyelination in adult animals. Primary demyelination can be caused by injury to oligodendrocytes or to the myelin sheaths that these cells maintain. Precisely timed motor learning promotes remyelination in the motor cortex by enhancing oligodendrogenesis and stimulating mature oligodendrocytes to generate new myelin, presenting mature. Invitrogen anti-oligodendrocyte marker o1 monoclonal (o1), ebioscience, catalog . Tested in immunofluorescence (if), immunocytochemistry (icc), immunohistochemistry (frozen) (ihc (f)), flow cytometry (flow) and elisa (elisa) applications. This antibody reacts with chicken, human, mouse, rat samples. Sox6 olig2 nogo cells (top) are opcs, nogo olig2 sox6 cells are mature oligodendrocytes.

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