In contrast, only hUNG2 accumulates in replication foci in the S-phase. Moreover, an additional but delayed repair of the U: We propose a model in which hUNG2 is responsible for both prereplicative removal of deaminated cytosine and postreplicative removal of misincorporated uracil at the replication fork. We also provide evidence that hUNG2 is the major enzyme for removal of deaminated cytosine outside of replication foci, with hSMUG1 acting as a broad specificity backup. Uracil in DNA can be introduced via two mechanisms, deamination of cytosine and misincorporation of dUMP during replication. The latter is not miscoding, but may produce cytotoxic and mutagenic AP site intermediates during repair.
hUNG2 in nuclear extracts initiates base excision repair of plasmids This pathway requires pol ε and/or δ, as well as the trimeric sliding clamp. Best Price Guarantee ➤ Nightly rates at Vinh Hung 2 City Hotel as low as $ Located in the Cam Very good. "Good location and enjoyed the breakfast.".
Located in heart of Hoi An. The historic town of Hoi An is one of Vietnam's biggest draws, and the Vinh Hung 2 Hotel does its part in sustaining this appeal. Located within Hoi An's Ancient City, the Vinh Hung 2 Hotel features 30 rooms designed in tasteful local architecture and also contains many modern amenities.
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